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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 61% Improvement Relative Risk ICU admission 56% Progression 59% c19sv.com Ong et al. Sotrovimab for COVID-19 EARLY TREATMENT Favors sotrovimab Favors control
Ong, 94 patient sotrovimab early treatment study: 56% lower ICU admission [p=0.35] and 59% lower progression [p=0.05] https://c19p.org/ong2
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Real-World Use of Sotrovimab for Pre-Emptive Treatment in High-Risk Hospitalized COVID-19 Patients: An Observational Cross-Sectional Study
Ong et al., Antibiotics, doi:10.3390/antibiotics11030345
5 Mar 2022    Source   PDF   Share   Tweet
Retrospective 19 sotrovimab patients and 75 controls is Singapore, showing lower progression with treatment.
Efficacy is variant dependent. Lower efficacy for BA.1 [Liu, Sheward, VanBlargan], unlikely to be effective for BA.2 [Zhou]. US EUA has been revoked.
risk of death, 60.5% lower, RR 0.39, p = 0.45, treatment 1 of 19 (5.3%), control 10 of 75 (13.3%), NNT 12.
risk of ICU admission, 56.1% lower, RR 0.44, p = 0.35, treatment 2 of 19 (10.5%), control 18 of 75 (24.0%), NNT 7.4.
risk of progression, 59.0% lower, HR 0.41, p = 0.047, treatment 19, control 75, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ong et al., 3/5/2022, retrospective, Singapore, Asia, peer-reviewed, 10 authors, average treatment delay 2.0 days.
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