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All Studies   Meta Analysis   Recent: 
Resistance conferring mutations in SARS-CoV-2 delta following sotrovimab infusion
Rockett et al., medRxiv, doi:10.1101/2021.12.18.21267628 (Preprint)
21 Dec 2021    Source   PDF   Share   Tweet
Retrospective 100 sotrovimab patients in Australia, 23 PCR+ more than 10 days post-infusion (68 with status unknown), showing rapid development of spike gene mutations that have been shown to confer high level resistance to sotrovimab in vitro.
Efficacy is variant dependent. Lower efficacy for BA.1 [Liu, Sheward, VanBlargan], unlikely to be effective for BA.2 [Zhou]. US EUA has been revoked.
Rockett et al., 12/21/2021, preprint, 26 authors.
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