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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality -2% Improvement Relative Risk Recovery 11% primary Recovery (b) 7% c19sv.com Self et al. NCT04501978 Sotrovimab RCT LATE TREATMENT Favors sotrovimab Favors control
Self, 360 patient sotrovimab late treatment RCT: 2% higher mortality [p=0.96] and 11% improved recovery [p=0.29] https://c19p.org/self3
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Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
Self et al., The Lancet Infectious Diseases, doi:10.1016/S1473-3099(21)00751-9
23 Dec 2021    Source   PDF   Share   Tweet
RCT with 182 sotrovimab patients and 178 control patients, median 8 days from symptom onset, showing no significant differences and terminated early due to futility. TICO. NCT04501978.
Efficacy is variant dependent. Lower efficacy for BA.1 [Liu, Sheward, VanBlargan], unlikely to be effective for BA.2 [Zhou]. US EUA has been revoked.
risk of death, 2.0% higher, RR 1.02, p = 0.96, treatment 14 of 182 (7.7%), control 13 of 178 (7.3%), day 90.
risk of no recovery, 10.7% lower, RR 0.89, p = 0.29, treatment 22 of 160 (13.8%), control 27 of 178 (15.2%), NNT 70, day 90, primary outcome.
risk of no recovery, 7.4% lower, RR 0.93, p = 0.69, treatment 160, control 178, pulmonary-plus ordinal outcome @day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Self et al., 12/23/2021, Double Blind Randomized Controlled Trial, multiple countries, multiple regions, peer-reviewed, 647 authors, study period 16 December, 2020 - 1 March, 2021, average treatment delay 8.0 days, trial NCT04501978.
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Late treatment
is less effective
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