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20 December 2021 - In Vitro
Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)
Sheward et al., bioRxiv, doi:10.1101/2021.12.19.473354 (Preprint) (In Vitro)
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In Vitro study showing that omicron is substantially resistant to neutralization by monoclonal antibodies REGN10933, REGN10987, Ly-CoV016 and Ly-CoV555. S309 (the parent of Sotrovimab) had only 2-fold loss in potency.
Sheward et al., 12/20/2021, preprint, 11 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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