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0 0.5 1 1.5 2+ Progression -165% Improvement Relative Risk c19sv.com Zaqout et al. Sotrovimab for COVID-19 EARLY TREATMENT Favors sotrovimab Favors control
Zaqout, 928 patient sotrovimab early treatment study: 165% higher progression [p=0.19] https://c19p.org/zaqout
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Effectiveness of the neutralizing antibody sotrovimab among high-risk patients with mild to moderate SARS-CoV-2 in Qatar
Zaqout et al., medRxiv, doi:10.1101/2022.04.21.22274060 (Preprint)
21 Apr 2022    Source   PDF   Share   Tweet
Retrospective 345 sotrovimab treated patients in Qatar matched with 583 patients that opted not to receive treatment, showing higher progression with treatment, without statistical significance.
Efficacy is variant dependent. Lower efficacy for BA.1 [Liu, Sheward, VanBlargan], unlikely to be effective for BA.2 [Zhou]. US EUA has been revoked.
risk of progression, 164.7% higher, RR 2.65, p = 0.19, treatment 4 of 345 (1.2%), control 3 of 583 (0.5%), adjusted per study, odds ratio converted to relative risk, progression to severe/critical disease or mortality.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Zaqout et al., 4/21/2022, retrospective, Qatar, Middle East, preprint, 17 authors, study period 20 October, 2021 - 28 February, 2022.
Contact: azaqout@hamad.qa.
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